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Transcript Comparison of Meniscus, OA and non-OA

Osteoarthritis Cartilage; ePub 2017 Dec 16; Brophy, et al

Numerous transcripts with potential relevance to the pathogenesis of osteoarthritis (OA) are differentially expressed (DE) in OA and non-OA menisci, a recent study found. These data suggest an involvement of epigenetically regulated histone deacetylation in meniscus tears as well as expression of long noncoding RNAs (lncRNAs). RNA microarrays were used to identify transcripts DE in meniscus obtained from 12 OA and 12 non-OA patients. The non-OA specimens were obtained at the time of arthroscopic partial meniscectomy (APM). Real-time PCR was performed on selected transcripts. Investigators found:

  • 168 transcripts significantly DE between OA (75 elevated, 93 repressed) and non-OA samples (≥1.5-fold) were identified.
  • Among these, CSN1S1, COL10A1, WIF1, and SPARCL1 were the most prominent transcripts elevated in OA meniscus, POSTN and VEGFA were most highly repressed in OA meniscus.
  • Transcripts elevated in OA meniscus represented response to external stimuli, cell-migration and cell-localization while those repressed in OA meniscus represented histone deacetylase activity (related to epigenetics) and skeletal development.

Citation:

Brophy RH, Zhang B, Cai L, Wright RW, Sandell LJ, Rai MF. Transcriptome comparison of meniscus from patients with and without osteoarthritis. [Published online ahead of print December 16, 2017]. Osteoarthritis Cartilage. doi:10.1016/j.joca.2017.12.004.

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