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Does Aspirin Prevent Preterm Preeclampsia?

Am J Obstet Gynecol; ePub 2017 Nov 11; Roberge, et al

Aspirin reduces the risk of preterm preeclampsia when it is initiated at ≤16 weeks of gestation and at a daily dose of ≥100 mg; however, it does not reduce the risk of term preeclampsia, a recent study found. The systematic review and meta-analysis evaluated the prophylactic effect of aspirin during pregnancy. Researchers found:

  • 16 trials including 18,907 participants provided data for preterm and term preeclampsia.
  • Administration of aspirin was associated with reduction in the risk of preterm preeclampsia (relative risk [RR], 0.62), but there was no significant effect on term preeclampsia (RR, 0.92).
  • The reduction in preterm preeclampsia was observed in the subgroup in which aspirin was initiated at ≤16 weeks’ gestation at a daily dose of ≥100 mg (RR, 0.33).

Citation:

Roberge S, Bujold E, Nicolaides KH. Aspirin for the prevention of preterm and term preeclampsia: Systematic review and meta-analysis. [Published online ahead of print November 11, 2017]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2017.11.561.

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