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Sleep Problems and Cognitive Dysfunction in MS

Behav Sleep Med; 2018 Jan-Feb; Hughes, et al

For individuals with multiple sclerosis (MS) and depression, fatigue, or pain, self-reported sleep problems are related to perceived cognitive dysfunction, and that fatigue impact accounts for part of this relationship, a recent study found. 163 individuals with MS and depression, fatigue, or pain completed self-report measures of sleep, cognitive dysfunction, and relevant demographic and clinical characteristics (eg, disability severity, depressive symptomatology, pain intensity, fatigue impact) at 4 time points over 12 months. Researchers found:

  • Mixed-effects regression demonstrated that poorer sleep was independently associated with worse perceived cognitive dysfunction (β=–0.05), beyond the influence of depressive symptomatology.
  • Fatigue impact was found to partially mediate this relationship.

Citation:

Hughes AJ, Turner AP, Alschuler KN, et al. Association between sleep problems and perceived cognitive dysfunction over 12 months in individuals with multiple sclerosis. Behav Sleep Med. 2018;16(1):79-91. doi:10.1080/15402002.2016.

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Potential Limitations of Balance Confidence Scales, Int J MS Care; ePub 2018 Jan 24; Wood, Wajda, et al

Cognitive Phenotypes in MS and Targeted Treatments, J Neurology; ePub 2018 Jan 22; Leavitt, Tosto, et al

Demographic Characteristics in Persons with MS, J Int Neuropsychol Soc; 2018 Feb; Costa, et al

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Must Reads in Multiple Sclerosis

Potential Limitations of Balance Confidence Scales, Int J MS Care; ePub 2018 Jan 24; Wood, Wajda, et al

Cognitive Phenotypes in MS and Targeted Treatments, J Neurology; ePub 2018 Jan 22; Leavitt, Tosto, et al

Demographic Characteristics in Persons with MS, J Int Neuropsychol Soc; 2018 Feb; Costa, et al

Mercy Evaluation of MS Appropriately Valid, Clin Neuropsychol; ePub 2018 Jan 23; Merz, et al

Walking Speed, Endurance Studied in Persons with MS, J Neurophysiol; ePub 2018 Jan 3; Almuklass, et al