Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Setting Plays Role in Evaluating Cognitive Decline

Alzheimers Dement; ePub 2018 Jan 17; Snitz, et al

Subjective cognitive decline (SCD) is more likely to progress to mild cognitive impairment (MCI) in a memory clinic than the general population, and participants' characteristics vary across settings, according to a recent study. Therefore, study setting should be considered when evaluating SCD as a risk state for MCI and dementia. Older adults presenting at a memory clinic were classified as SCD (n=113) or as noncomplainers (n=82). Participants from a population study were classified as SCD (n=592) and noncomplainers (n=589) based on a memory complaint score. Annual follow-up wasperformed for a mean of 3 years. Researchers found that the adjusted hazard ratio for SCD was 15.97 in the memory clinic vs 1.18 in the population study, where reported “worry” about memory further increased SCD-associated risk for MCI.


Snitz BE, Wang T, Cloonan YK, et al. Risk of progression from subjective cognitive decline to mild cognitive impairment: The role of study setting. [Published online ahead of print January 17, 2018]. Alzheimers Dement. doi:10.1016/j.jalz.2017.12.003.

This Week's Must Reads

Diet Characteristics Examined in People with MS, Mult Scler Relat Disord; ePub Feb 27; Fitzgerald, et al

Cognitive Fatigue Examined in Patients with MS, Mult Scler; 2018 Feb; Golan, Doniger, et al

Community Isolation, Functional Connectivity in MS, Brian Struct Funct; ePub 2018 Feb 16; Patel, et al

New Technique Accurately Estimates MS Lesion Size, Am J Neuroradiol; ePub 2018 Feb 22; Dworkin, Linn, et al

MS, Crohn’s Share Similar Birth-Cohort Patterns , Mult Scler; 2018 Feb; Sonnenberg, Ajdacic-Gross

Must Reads in Alzheimer's & Cognition

Neighborhoods, Sleep Quality, and Cognitive Decline, Alzheimers Dement; ePub 2018 Feb 3; Hunter, et al

AD, Rest-Activity Rhythm Fragmentation Linked , JAMA Neurology; ePub 2018 Jan 29; Musiek, et al

Setting Plays Role in Evaluating Cognitive Decline, Alzheimers Dement; ePub 2018 Jan 17; Snitz, et al

AD Biomarkers Lead to Earlier Driving Cessation, Alzheimers Dement; ePub 2018 Jan 9; Stout, et al

Better CVH Linked with Reduced Cognition Decline, Alzheimers Dementia; ePub 2017 Dec 18; González, et al