Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Gender and Survival in Patients with ET

Am J Hematol; ePub 2017 Aug 28; Tefferi, et al

Women with essential thrombocythemia (ET) live longer than their male counterparts, according to a study involving nearly 1,500 individuals. In fact, gender might carry more weight than thrombosis history when predicting overall survival. One group of participants were from the Mayo Clinic (n=904). They had ET and were a median of 58 years of age. ~Two-thirds were female. Investigators analyzed them by international ET prognostic (IPSET) score, and then confirmed findings in a validation cohort. Among the results:

  • Males were 60% more likely to experience shortened survival.
  • Patients ≥60 years of age and those with leukocyte count ≥11 × 10(9)/L were also more likely to experience such.
  • The findings were confirmed in the validation cohort.
  • The survival disadvantage in men was highest in patients in the IPSET high risk category, and those >60 years of age.
  • Thrombosis history was not a significant predictor after multivariable analysis.


Tefferi A, Betti S, Barraco D, et al. Gender and survival in essential thrombocythemia: A two-center study of 1,494 patients. [Published online ahead of print August 28, 2017]. Am J Hematol. doi:10.1002/ajh.24882.

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