Diabetes mellitus (DM) is associated with increased rates of all-cause mortality and major adverse events after left ventricular assist device (LVAD) implantation, despite favorable glycemic control, a recent study suggests. 341 consecutive adults who underwent implantation of LVAD from 2007 to 2016 were retrospectively reviewed. Patient characteristics and adverse events were studies and compared between patients with and without DM. Researchers found:
- 133 (38%) patients had DM.
- Compared with patients without DM, those with DM had higher rates of ischemic cardiomyopathy, LVAD implantation as destination therapy, and increased baseline body mass index (BMI).
- At median follow-up of 16.1 months, DM was associated with increased risk of all-cause mortality (HR, 1.73) and increased risk of nonfatal LVAD-related complications (HR, 2.1).
- LVAD implantation resulted in a significant decrease in hemoglobin A1c levels and reduction in requirements of DM medications.
Asleh R, Briasoulis A, Schettle SD, et al. Impact of diabetes mellitus on outcomes in patients supported with left ventricular assist devices. [Published online ahead of print November 15, 2017]. Circ Heart Fail. doi:10.1161/CIRCHEARTFAILURE.117.004213.
This Week's Must Reads
HCV and Increased Risk of Atherosclerosis, Hepatol Int; ePub 2018 Feb 8; Bridge, et al
Chronic HCV & Early HIV Viral Response to ART, AIDS; ePub 2018 Jan 13; Willis, Cole, et al
Impact of DM/HBV Coinfection in Patients with HCV, J Gastroenterol Hepatol; ePub 2018 Jan 26; Subramaniam, et al
Prevalence of HCV and Route of Transmission, J Viral Hepat; 2018 Feb; Wong, Lee, Ng, et al
Liver Fibrosis & Microbial Translocation in HIV/HCV, J Infect Dis; ePub 2018 Jan 3; Reid, et al
Must Reads in Cardiology
Can Omega-3 Supplement Use Lower CVD Risk?, JAMA Cardiol; ePub 2018 Jan 31; Aung, et al
Adherence Rates to Secondary Prevention Meds, Circulation; ePub 2018 Jan 31; Mathews, et al
Catheter Ablation for AF in Patients with HF, N Engl J Med; 2018 Feb 1; Marrouche, et al
Changes in Physical Activity & Risk of HF, Circulation; ePub 2018 Jan 31; Florido, et al
Should Patients with Syncope be Evaluated for PE?, JAMA Intern Med; ePub 2018 Jan 29; Costantino, et al