Safety and Efficacy Comparison of Maximum Dose Simvastatin vs Rosuvastatin

Heart disease remains the leading cause of death in the U.S., and studies have shown that elevated low-density lipoprotein cholesterol (LDL-C) is a major cause of coronary artery disease (CAD).(1-5) Lipid-lowering therapy, including simvastatin and rosuvastatin, has an important role in the reduction of LDL-C and primary and secondary prevention of CAD.(6) Within the VA Health Care System (VAHCS), simvastatin plays a major role in lipid management, because it is a formulary agent.