Possible simeprevir/sofosbuvir-induced hepatic decompensation with acute kidney failure

In this case report, the authors describe their experience in caring for a 62-year-old man with hepatic decompensation and acute kidney injury that was caused by simeprevir/sofosbuvir initiation for chronic hepatitis C (HCV). In the article, which is available at https://www.fedprac.com/the-publication/issue-single-view/possible-simeprevirsofosbuvir-induced-hepatic-decompensation-with-acute-kidney-failure/4aa123f84bba6831d73a86fd67565a5e/ocregister.html, the authors advise that careful consideration is needed prior to the initiation of simeprevir/sofosbuvir—particularly in patients with advanced liver disease or known hepatocellular carcinoma and baseline renal impairment.