iPLEDGE and Its Implementation in Dermatology Practices

Isotretinoin is one option in a dermatologist’s arma­mentarium for the treatment of acne; however, it is highly teratogenic, and fetal exposure to isotretinoin can cause severe complications. iPLEDGE is a computer-based risk management program designed to help elimi­nate fetal exposure to isotretinoin by mandating how all isotretinoin products are prescribed and dispensed. Optimal success of the iPLEDGE program requires physi­cian prescribers along with their office staff and patients to perform specific responsibilities to ensure that patients do not start isotretinoin therapy while pregnant or become pregnant during treatment. We discuss how to successfully implement the iPLEDGE program in derma­tology practices.