Women at higher risk for CRC death after adenoma removal

Key clinical point: Women who underwent adenoma removal appear to be at a higher risk for colorectal cancer (CRC) incidence and CRC-related deaths, highlighting the need for sex-specific surveillance after adenoma removal.

Major finding: Compared with general population, CRC incidence was higher in women (standardized incidence ratios [SIR], 1.64; 95% CI, 1.54-1.74) than in men (SIR, 1.12; 95% CI, 1.05-1.19) who had adenomas removed. CRC mortality increased in women (standardized incidence-based mortality ratios [SMR], 1.13; 95% CI, 1.02-1.26) and reduced in men (SMR, 0.79; 95% CI, 0.71-0.89) who underwent adenoma removal compared with general population.

Study details: Findings are from a cohort study of 40,293 individuals who had their adenomas removed.

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Disclosures: This work was supported by grants from Norwegian Research Council and Norwegian Cancer Society. The authors declared no conflict of interests.

Source: Jodal HC et al. Aliment Pharmacol Ther. 2021 Oct 30. doi: 10.1111/apt.16686.