When PPI Therapy Cures Chronic Diarrhea, Suspect ZES

Zollinger-Ellison syndrome (ZES), a rare condition caused by a gastrin secreting tumor of duodenopancreatic origin, is notoriously hard to diagnose. But clinicians should suspect this syndrome, say physicians from Saarland University Hospital, Hamburg, Germany, when chronic, unexplained diarrhea is alleviated by proton pump inhibitor (PPI) therapy.