Tissue Necrosis After Use of Enoxaparin in Total Knee Arthroplasty: A Case Report

Tissue necrosis at the injection site of enoxaparin is a rare adverse effect. Most of the reported clinical course of this necrosis is uneventful. Here we review a case of tissue necrosis that developed after use of enoxaparin and required debridement followed by reconstructive surgery. Until now, such a case has not been reported in the English-language literature. As enoxaparin is being used more often for prevention of deep vein thrombosis in patients who undergo arthroplasty surgery, aware­ness and recognition of this adverse event and careful supervision of all patients who receive this medication are essential.