Prochlorperazine more effective than ketorolac for pediatric migraine
The Journal of Family Practice. 2004 June;53(6):442-450
June 1, 2004|The Journal of Family Practice
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- CLINICAL QUESTION: Is ketorolac more effective than prochlorperazine in the treatment of pediatric migraine in the emergency setting?
- STUDY DESIGN: Randomized controlled trial (double-blinded)
- SETTING: Emergency department
- SYNOPSIS: This study is a start in the right direction toward clearing up the lack of information regarding treatment of pediatric migraine in the emergency department. The investigators recruited 62 children aged 5 to 18 years presenting with migraine in either of 2 pediatric emergency departments. Migraine was defined as recurrent headache with at least 3 of the following symptoms: an aura; unilateral location; throbbing pulsatile pain; nausea, vomiting, or abdominal pain; relief after sleep; and a family history of migraine.
BOTTOM LINE
Prochlorperazine (Compazine) is more effective than ketorolac (Toradol) in the treatment of children presenting to the emergency department with migraine. One additional child will experience headache relief for every 4 children receiving prochlorperazine instead of ketorolac. (LOE=1b)
