This article has been peer reviewed and approved by Michael Fisher, MD, Professor of Medicine, Albert Einstein College of Medicine. Review date: September 2009.
Drs. Gendernalik and Galeckas report no conflict of interest. The authors report no discussion of off-label use. Dr. Fisher reports no conflict of interest. The staff of CCME of Albert Einstein College of Medicine and Cutis® have no conflicts of interest with commercial interest related directly or indirectly to this educational activity. Dr. Gendernalik is a flight surgeon, Naval Air Station Whidbey Island, Oak Harbor, Washington. Dr. Galeckas is a staff dermatologist, National Naval Medical Center, Bethesda, Maryland. The views experessed in this article are those of the authors and do not reflect the official policy or position of the US Department of the Navy, the US Department of Defense, or the US Government.
Sarah B. Gendernalik, DO; Kenneth J. Galeckas, MD
Fixed drug eruptions (FDEs) have been described since 1889 with continually evolving documentation of implicated agents and clinical presentations. We report a case of FDE as a reaction to naproxen sodium in a 27-year-old woman. We offer an inventory of common causes of FDEs as well as a discussion of the spectrum of clinical presentations and differential diagnoses for this peculiar drug reaction.
