Changes in Brain Networks May Predict MS Worsening

Key clinical point: Structural and functional network MRI measures predict long-term worsening in multiple sclerosis.

Major finding: The odds ratio of worsening for patients with abnormally high baseline resting state functional connectivity is 1.67.

Study details: A prospective imaging study of 233 patients with multiple sclerosis and 77 healthy controls.

Disclosures: Dr. Filippi has received research support from Biogen, Merck Serono, Novartis, Teva, and Roche.

Citation: Filippi M et al. AAN 2019, Abstract S49.004.