Autoimmune Diseases Increase PsA Risk
Key clinical point: Patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), and certain other autoimmune diseases (AID) may have an increased risk of developing psoriatic arthritis (PsA).
Major finding: The risk factors for PsA included RA (inverse variance weighting odds ratio [ORIVW] 1.11; P = .0205), SLE (ORIVW 1.04; P = .0107), AS (ORIVW 2.18; P = .000155), Crohn's disease (CD; ORIVW 1.07; P = .01), Hashimoto's thyroiditis (HT; ORIVW 1.23; P = .00143), and vitiligo (ORIVW 1.27; P = .0000267). However, PsA did not increase the risk for these AID.
Study details: This bidirectional two-sample Mendelian randomization study used genome-wide association data for PsA (3186 cases and 240,862 control individuals and an additional 5065 cases and 21,286 control individuals), psoriasis, and AID.
,Disclosures: This study was supported by two research projects from China. The authors declared no conflicts of interest.
Source: Duan K, Wang J, Chen S, et al. Causal associations between both psoriasis and psoriatic arthritis and multiple autoimmune diseases: A bidirectional two-sample Mendelian randomization study. Front. Immunol. 2024;15:1422626 (Jul 24). Doi: 10.3389/fimmu.2024.1422626 Source