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Acute stroke therapy: Beyond IV tPA

Cleveland Clinic Journal of Medicine. 2002 September;69(9):730-734
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ABSTRACTAlthough intravenous tissue plasminogen activator (IV tPA) has been approved for treating acute ischemic stroke, it must be given within 3 hours of stroke onset and only after ruling out hemorrhagic stroke by computed tomography. Several medical centers are turning to angiography to guide intra-arterial infusion of thrombolytic agents and mechanical endovascular interventions.