Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Dysglycemia Cause in Overweight Adults, Teens

Diabetes Care; ePub 2017 Nov 28; Chen, et al

Adults and adolescents have dissimilar underlying defects that lead to dysglycemia, according to a study involving 139 individuals. Participants included adults (n=89) and adolescents (n=50) with normal glucose tolerance (NGT), dysglycemia, or type 2 diabetes. Investigators used oral glucose tolerance test results for C-peptide and insulin/glucose minimal modeling, and compared insulin secretion and insulin sensitivity across glycemic stages and between age groups at each stage. Among the results:

  • Adolescents with dysglycemia had marked insulin resistance, with median insulin sensitivity index score of 1.8, vs 5.0 for adults.
  • The nature of β-cell dysfunction across stages of dysglycemia differed between the groups.
  • There were higher levels of insulin secretion in adolescents compared with adults.
  • Adults showed stepwise impairments in static insulin secretion.
  • Adolescents showed diabetes-related impairment in dynamic secretion.

The authors noted that their findings point to the need for different diabetes prevention approaches in youths and adults.

Citation:

Chen M, Chandramouli A, Considine R, Hannon T, Mather K. Comparison of β-Cell function between overweight/obese adults and adolescents across the spectrum of glycemia. [Published online ahead of print November 28, 2017]. Diabetes Care. doi:10.2337/dc17-1373.

This Week's Must Reads

Glucose Predicts Mortality in Surgical Patients , Diabetes Care; ePub 2018 Feb 13; van den Boom, et al

These Limb-Specific Factors Predict Amputation, Diabetes Care; ePub 2018 Feb 8; Boyko, et al

Adiposity’s Impact in Mexican-Americans Studied , Obesity; ePub 2018 Feb 10; Black, Shu, Wu, et al

Mortality Is Rising in These People with Diabetes , Diabetes Care; ePub 2018, Feb 7; Kramer, et al

T2D Continuous Care Model Compared to Usual Care, Diabetes Ther; ePub 2018 Feb 7; Hallberg, et al

Must Reads in Diabetes

Glucose Predicts Mortality in Surgical Patients , Diabetes Care; ePub 2018 Feb 13; van den Boom, et al

These Limb-Specific Factors Predict Amputation, Diabetes Care; ePub 2018 Feb 8; Boyko, et al

Mortality Is Rising in These People with Diabetes , Diabetes Care; ePub 2018, Feb 7; Kramer, et al

T2D Continuous Care Model Compared to Usual Care, Diabetes Ther; ePub 2018 Feb 7; Hallberg, et al

Sulfonylureas and Cardiac Outcomes Evaluated, Diabetes Care; ePub 2018 Feb 2; Leonard, et al