Brian F. Mandell, MD, PhD Department of Rheumatic and Immunologic Diseases, Vice-Chairman of Medicine for Education, The Cleveland Clinic Foundation; Deputy Editor, Cleveland Clinic Journal of Medicine
Address: Brian F. Mandell, MD, PhD, Department of Rheumatic and Immunologic Diseases, A50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail mandelb@ccf.org
Medical Grand Rounds articles are based on edited transcripts from Division of Medicine Grand Rounds presentations at The Cleveland Clinic. They are approved by the author but are not peer-reviewed.
This paper discusses therapies that are experimental or are not approved by the US Food and Drug Administration for the use under discussion.
ABSTRACTPolymyalgia rheumatica should be considered in the differential diagnosis in patients over 50 years old who present with bilateral achiness and stiffness in the shoulders or hips or both. It usually responds quickly to once-daily, low-dose prednisone, but some patients require treatment for several years. Polymyalgia rheumatica frequently overlaps with giant cell arteritis, and patients must be followed closely for development of complications from this condition, especially aortitis.