Obesity and advanced stage at diagnosis worsen recurrence rate in BC patients

Key clinical point: Obesity and advanced stage (stage III) at diagnosis of breast cancer (BC) were associated with a higher rate of recurrence and worse prognosis in patients with BC who achieved pathological complete response (pCR) after receiving neoadjuvant chemotherapy (NCT).

Major finding: Obesity vs  no obesity (P = .019) and stage III vs  stage I-II BC at diagnosis (P = .0018) were significantly associated with worse invasive disease-free survival, with obesity demonstrating worse survival outcomes in stage III BC (hazard ratio 4.31; P = .006).

Study details: Findings are from a retrospective real-world analysis including 241 patients with stage I-III BC who had achieved pCR after receiving NCT.

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Disclosures: This study did not receive any funding. The authors declared no conflicts of interest.

Source: Acevedo F et al. Obesity is associated with early recurrence on breast cancer patients that achieved pathological complete response to neoadjuvant chemotherapy. Sci Rep. 2022;12:21145 (Dec 7). Doi: 10.1038/s41598-022-25043-2