Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

PET: Imaging Biomarker for Large-Vessel Vasculitis

Arthritis Rheumatol; ePub 2017 Nov 16; Grayson, et al

18F-flurodeoxyglucose (FDG) positron emission tomography (PET) provides information about vascular inflammation that is complimentary to, and unique from, clinical assessment in large-vessel vasculitis (LVV), a recent study found. Furthermore, FDG-PET scan activity during clinical remission was associated with future clinical relapse. Patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA) were studied, along with a comparator group consisting of patients with hyperlipidemia, diseases that mimic LVV, and healthy controls. Participants underwent clinical evaluation and FDG-PET imaging, and patients with LVV underwent serial imaging at 6-month intervals. 170 FDG-PET scans were performed in 115 participants (LVV=56; comparators=59). Researchers found:

  • FDG-PET differentiated patients with clinically active LVV and disease comparators with a sensitivity=85% and specificity=83%.
  • FDG-PET scans were interpreted as active vasculitis in most patients with LVV in clinical remission (41 of 71, 58%).
  • Clinical disease activity status, disease duration, body mass index, and glucocorticoid use were independently associated with PET scan activity.

Citation:

Grayson PC, Alehashemi S, Bagheri AA, et al. Positron emission tomography as an imaging biomarker in a prospective, longitudinal cohort of patients with large vessel vasculitis. [Published online ahead of print November 16, 2017]. Arthritis Rheumatol. doi:10.1002/art.40379.

This Week's Must Reads

Excess Weight Has Negative Impact on RA, Arthritis Care Res; ePub 2017 Nov 30; Schulman, et al

Severe Weight Loss, RA & Mortality in Women, Arthritis Rheumatol; ePub 2017 Nov 30; Sparks, et al

Youth: High Health Care Use Prior to SLE Diagnosis, Arthritis Care Res; ePub 2017 Dec 1; Chang, et al

AS Pain May Derive from Spinal Inflammation Alone, J Rheumatol; ePub 2017 Dec 1; Dau, Lee, Ward, et al

Joint Replacement Surgery Trends in Those with RA, J Rheumatol; ePub 2017 Dec 1; Young, Watson, et al

Must Reads in Lupus & Connective Tissue Diseases

Youth: High Health Care Use Prior to SLE Diagnosis, Arthritis Care Res; ePub 2017 Dec 1; Chang, et al

Sex Differences in Healthcare Utilization in LN, Arthritis Rheumatol; ePub 2017 Nov 28; Feldman, et al

Markers for GI Dysmotility in Systemic Sclerosis, Arthritis Care Res; ePub 2017 Nov 28; McMahan, et al

PET: Imaging Biomarker for Large-Vessel Vasculitis, Arthritis Rheumatol; ePub 2017 Nov 16; Grayson, et al

Study: Premature Mortality Rates in SLE Unchanged, Rheumatology (Oxford); ePub 2017 Nov 7; Jorge, et al