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Markers for GI Dysmotility in Systemic Sclerosis

Arthritis Care Res; ePub 2017 Nov 28; McMahan, et al

Distinct clinical features are present in systemic sclerosis (SSc) patients who are at risk of developing severe gastrointestinal (GI) dysmotility, according to a recent study. This finding is not only important clinically but also suggests that a unique pathological process is present in these patients. Patients with SSc who required supplemental nutrition (enteral or parental tube feeding) were compared to SSc patients with mild GI symptoms in a cross-sectional analysis. The association between severe GI dysmotility and clinical and serological features was examined using logistic regression. Researchers found:

  • SSc patients with severe GI dysmotility (n=66) were more likely than those patients with mild GI symptoms (n=1,736) to be male, have myopathy, and sicca symptoms, even after adjusting for potential confounders.
  • Baseline features that associate with the future development of severe GI dysfunction included male sex and myopathy.

Citation:

McMahan Z, Paik JJ, Wigley FM, Hummers LK. Determining the risk factors and clinical features associated with severe gastrointestinal dysmotility in systemic sclerosis. [Published online ahead of print November 28, 2017]. Arthritis Care Res. doi:10.1002/acr.23479.

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