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Sleep Problems and Cognitive Dysfunction in MS

Behav Sleep Med; 2018 Jan-Feb; Hughes, et al

For individuals with multiple sclerosis (MS) and depression, fatigue, or pain, self-reported sleep problems are related to perceived cognitive dysfunction, and that fatigue impact accounts for part of this relationship, a recent study found. 163 individuals with MS and depression, fatigue, or pain completed self-report measures of sleep, cognitive dysfunction, and relevant demographic and clinical characteristics (eg, disability severity, depressive symptomatology, pain intensity, fatigue impact) at 4 time points over 12 months. Researchers found:

  • Mixed-effects regression demonstrated that poorer sleep was independently associated with worse perceived cognitive dysfunction (β=–0.05), beyond the influence of depressive symptomatology.
  • Fatigue impact was found to partially mediate this relationship.

Citation:

Hughes AJ, Turner AP, Alschuler KN, et al. Association between sleep problems and perceived cognitive dysfunction over 12 months in individuals with multiple sclerosis. Behav Sleep Med. 2018;16(1):79-91. doi:10.1080/15402002.2016.

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