Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Sleep Problems and Cognitive Dysfunction in MS

Behav Sleep Med; 2018 Jan-Feb; Hughes, et al

For individuals with multiple sclerosis (MS) and depression, fatigue, or pain, self-reported sleep problems are related to perceived cognitive dysfunction, and that fatigue impact accounts for part of this relationship, a recent study found. 163 individuals with MS and depression, fatigue, or pain completed self-report measures of sleep, cognitive dysfunction, and relevant demographic and clinical characteristics (eg, disability severity, depressive symptomatology, pain intensity, fatigue impact) at 4 time points over 12 months. Researchers found:

  • Mixed-effects regression demonstrated that poorer sleep was independently associated with worse perceived cognitive dysfunction (β=–0.05), beyond the influence of depressive symptomatology.
  • Fatigue impact was found to partially mediate this relationship.


Hughes AJ, Turner AP, Alschuler KN, et al. Association between sleep problems and perceived cognitive dysfunction over 12 months in individuals with multiple sclerosis. Behav Sleep Med. 2018;16(1):79-91. doi:10.1080/15402002.2016.

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