Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

CD8+ Tumor-Infiltrating Lymphocytes and Ovarian Ca

JAMA Oncol; ePub 2017 Oct 12; OTTA Consortium

There appears to be a dose-response relationship between CD8+ tumor-infiltrating lymphocytes (TILs) and high-grade serous ovarian carcinoma survival, according to a multicenter observational, prospective survival cohort study involving >5,500 women. Participants were diagnosed at an average of ~58 years of age and included patients with high-grade serous ovarian carcinomas (HGSOCs; n=3,196). Investigators grouped patients based on the estimated number of CD8+ TILs, and looked at overall survival time. Among the results:

  • HGSOCs showed the most infiltration.
  • Median survival was 2.8 years for patients with no CD8+ TILs.
  • In patients with low, moderate, or high levels of CD8+ TILs it was 3, 3.8, and 5.1 years, respectively.
  • Survival benefit was seen among women with endometrioid and mucinous carcinomas.
  • Among HGSOCs, CD8+ TILs were favorable regardless of extent of residual disease following cytoreduction, known standard treatment, and germline BRCA1 pathogenic mutation.
  • They were not prognostic for BRCA2 mutation carriers.

Citation:

Ovarian Tumor Tissue Analysis (OTTA) Consortium. Dose-response association of cd8+ tumor-infiltrating lymphocytes and survival time in high-grade serous ovarian cancer. [Published online ahead of print October 12, 2017]. JAMA Oncol. doi:10.1001/jamaoncol.2017.3290.

This Week's Must Reads

Cochrane on Bisphosphonates for Breast Cancer, Cochrane; 2017 Oct 30; O'Carrigan, Wong, et al

Fiber Intake and Survival After CRC Diagnosis, JAMA Oncol; ePub 2017 Nov 2; Song, Wu, et al

Selecting Patients with Advanced NSCLC for Chemo, JAMA Oncol; ePub 2017 Nov 1; Shen, Chang, et al

Predicting CV Risk in Childhood Cancer Survivors, J Clin Oncol; ePub 2017 Nov 2; Chow, Chen, et al

CD8+ Tumor-Infiltrating Lymphocytes and Ovarian Ca, JAMA Oncol; ePub 2017 Oct 12; OTTA Consortium

Must Reads in Gynecologic Cancer

CD8+ Tumor-Infiltrating Lymphocytes and Ovarian Ca, JAMA Oncol; ePub 2017 Oct 12; OTTA Consortium

Lymph Node Removal During Endometrial Ca Surgery, Cochrane; 2017 Oct 2; Frost, Webster, et al

Cochrane on Reducing Neoplasia in Molar Pregnancy, Cochrane; 2017 Sep 11; Wang, Fu, Hu, et al

FDA Approves First Biosimilar to Treat Cancer, FDA news release; 2017 Sep 14

HPV vs Pap Test for Cervical Cancer Screening, Cochrane; 2017 Aug 10; Koliopoulos, Nyaga, et al