Hospital-level antibiotic consumption may have an immediate and prolonged impact on incident health-care facility-onset Clostridium difficile infection (CDI), a recent study found. The single-center, ecologic study characterized the relationship between facility-wide antibiotic consumption and incident health care facility-onset CDI (HO-CDI). Facility-wide antibiotic consumption and incident HO-CDI were equated monthly and standardized from January 2013 through April 2015. Researchers determined:
- There was a matched-months correlation between ceftriaxone and HO-CDI.
- Delayed temporal associations may exist between antibiotic use and CDI.
- Antibiotic consumption may convey extended ward-level risk for incident CDI.
Crew PE, Rhodes NJ, O’Donnell JN, et al. Correlation between hospital-level antibiotic consumption and incident health care facility-onset Clostridium difficile infection. [Published online ahead of print November 21, 2017]. Am J Infect Control. doi:10.1016/j.ajic.2017.09.015.
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