Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Hospital-Level Antibiotic Consumption & Incident CDI

Am J Infect Control; ePub 2017 Nov 21; Crew, et al

Hospital-level antibiotic consumption may have an immediate and prolonged impact on incident health-care facility-onset Clostridium difficile infection (CDI), a recent study found. The single-center, ecologic study characterized the relationship between facility-wide antibiotic consumption and incident health care facility-onset CDI (HO-CDI). Facility-wide antibiotic consumption and incident HO-CDI were equated monthly and standardized from January 2013 through April 2015. Researchers determined:

  • There was a matched-months correlation between ceftriaxone and HO-CDI.
  • Delayed temporal associations may exist between antibiotic use and CDI.
  • Antibiotic consumption may convey extended ward-level risk for incident CDI.

Citation:

Crew PE, Rhodes NJ, O’Donnell JN, et al. Correlation between hospital-level antibiotic consumption and incident health care facility-onset Clostridium difficile infection. [Published online ahead of print November 21, 2017]. Am J Infect Control. doi:10.1016/j.ajic.2017.09.015.

This Week's Must Reads

Seasonal Incidence of Symptomatic Influenza in US, Clin Infect Dis; ePub 2017 Dec 1; Tokars, et al

Sustaining Reduction Rates for Hospital-Onset CDI, Am J Infect Control; ePub 2017 Nov 21; Khoury, et al

Prevalence of Anal HPV Infection in Men with HIV, J Infect Dis; ePub 2017 Dec 4; Patel, Bush, et al

Inflammation, Coagulation & Risk in ART Initiation, Open Forum Infect Dis; ePub 2017 Nov 28; Baker, et al

FDA Approves Isentress for Tx of HIV in Newborns, Merck news release; 2017 Nov 29

Must Reads in Antimicrobial Resistance

Hospital-Level Antibiotic Consumption & Incident CDI, Am J Infect Control; ePub 2017 Nov 21; Crew, et al

Antimicrobial Stewardship in Pediatric Facilities, Am J Infect Control; ePub 2017 Nov 15; Johnson, et al

Antibiotic Exposure & Risk of Subsequent Sepsis, Clin Infect Dis; ePub 2017 Nov 9; Baggs, et al

Duration of Antibiotic Use in Adults with CAP, Clin Infect Dis; ePub 2017 Nov 6; Yi, et al

Risk Factors for Community-Associated CDI, Open Forum Infect Dis; ePub 2017 Oct 26; Guh, et al