Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Psoriasis, PsA Associated with Liver Disease

J Invest Dermatol; ePub 2017 Nov 2; Ogdie, et al

More so than rheumatoid arthritis (RA), psoriasis (PsO) and psoriatic arthritis (PsA) are associated with liver disease, particularly non-alcoholic fatty liver disease (NAFLD) and cirrhosis, and this was true even among patients without systemic therapy (ST) exposure, according to a recent study. Researchers performed a cohort study among patients with PsO, PsA, or RA and matched controls in The Health Improvement Network from 1994-2014. Outcomes of interest were any liver disease, NAFLD, and cirrhosis (any etiology). They found:

  • Among patients with psoriasis (n=197,130), PsA (n=12,308), RA (n=54,251), and matched controls (n=1,279,754), the adjusted hazard ratios for any liver disease were elevated among patients with PsO, PsA, and RA without a ST but not elevated in RA patients prescribed a ST.
  • Incident NAFLD was highest in patients with PsO prescribed a ST and PsA with a ST.
  • Risk of cirrhosis was highest among patients with PsO with a ST and PsA without a ST.
  • Additionally, the prevalence of liver disease and cirrhosis increased in a stepwise fashion with increasing body surface area affected by PsO.

Citation:

Ogdie A, Grewal SK, Noe MH, et al. Risk of incident liver disease in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis: A population-based study. [Published online ahead of print November 2, 2017]. J Invest Dermatol. doi:10.1016/j.jid.2017.10.024.

This Week's Must Reads

SK: Strong Risk Predictor of Developing AV Block, Clin Cardiol; ePub 2017 Nov 23; Roshdy, et al

TADA Compares Favorably as Diagnostic Tool, Dermatol Pract Concept; 2017 Apr; Rogers, et al

Diagnosis of SK Is Challenging to the Naked Eye , J Dermatol; 2017 May; Minagawa

Genetic Alterations in Seborrheic Keratoses, Oncotarget; 2017 May; Heidenreich, et al

Rare Cutaneous Benign Tumor (RASD) Can Mimic SK , Dermatol Pract Concept; 2017 Jul; Ribiero, Leocadia, et al

Must Reads in Psoriasis

Psoriasis and Diabetes Risk Examined in Cohort, J Am Acad Dermatol; ePub 2017 Nov 8; Wan, et al

Psoriasis, PsA Associated with Liver Disease, J Invest Dermatol; ePub 2017 Nov 2; Ogdie, et al

FDA Approves Stelara for Adolescent Psoriasis, Janssen news release; 2017 Oct 13

FDA Approves Tremfya for Plaque Psoriasis, Janssen Biotech Inc. news release; 2017 Jul 13

Dietary Behaviors of Patients with Psoriasis, Dermatol Ther; ePub 2017 May 19; Afifi, Danesh, et al