Late-life depressive symptoms may partially mediate the association of subclinical cardiovascular disease (CVD) with mild cognitive impairment (MCI)/dementia onset, a recent study found. Among participants from the Cardiovascular Health Study Cognition Study who did not have baseline CVD-related events (n=2,450), causal mediation methodology was implemented to examine whether late-life depressive symptoms, defined as 10-item Center for Epidemiologic Studies-Depression Scale scores ≥8 from 2-3 years after baseline, partially mediated the association of baseline subclinical CVD (CAC, carotid intimal medial thickness, stenosis, and ankle brachial index) with MCI/dementia onset occurring between 5-10 years from baseline. Researchers found:
- Participants contributed 20,994 person-years of follow-up with a median follow-up time of 9.4 years.
- Subclinical CVD was associated with 12% faster time to MCI/dementia.
- The total effect of subclinical CVD on MCI/dementia onset was decomposed into a direct effect and indirect effect.
- 64.5% of the total effect was mediated by late-life depressive symptoms.
Armstrong NM, Carlson MC, Schrack J, et al. Late-life depressive symptoms as partial mediators in the associations between subclinical cardiovascular disease with onset of mild cognitive impairment and dementia. [Published online ahead of print November 20, 2017]. Am J Gertiatr Psychiatry. doi:10.1016/j.jagp.2017.11.004.
This Week's Must Reads
Study: Gender Is Central to Sexual Attraction, J Sex Res; ePub 2017 Nov 30; Schudson, et al
High-Risk Patients, Low-Volume Opioid Prescribers, Addiction; ePub 2017 Nov 29; Chang, Murimi, et al
Potential Risk Factors for Nonsuicidal Self-Injury, Psychiatry Res; ePub 2017 Nov 30; Fox, et al
FDA Grants Approval for Opioid Withdrawal Device, FDA news release; 2017 Nov 15
FDA Approves First US Digital Medicine System, FDA news release; 2017 Nov 14
Must Reads in Alzheimer's & Cognition
CVD, Late-Life Depression, Dementia Link Examined, Am J Geriatr Psychiatry; ePub 2017 Nov 20; Armstrong, et al
Age of First Exposure to Football Evaluated , Transl Psychiatry; ePub 2017 Sep 19; Alosco, et al
No Preclinical Dementia Personality Change Found, JAMA Psychiatry; ePub 2017 Sep 20; Terracciano, et al
Antidepressant Use and Reduced Hazard of Eventual AD, Int J Geriatr Psychiatry; ePub 2017 May 31; Burke, et al
Shared Mechanism Found in Cognitive Impairment, JAMA Psychiatry; ePub 2017 May 3; Sheffield, et al