Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cochrane on Delaying Diabetes in People with IGT

Cochrane; 2017 Dec 5; Hemmingsen, et al

Diet plus physical activity reduces or delays type 2 diabetes incidence in people with impaired glucose tolerance, according to a Cochrane review of 12 randomized controlled trials involving >5,000 individuals. Among the specific findings:

  • In 11 studies comparing diet plus physical activity with standard or no treatment, fewer patients receiving the intervention developed diabetes (15% vs 26% overall).
  • In 2 studies comparing physical activity with standard treatment, fewer physical activity patients developed type 2 diabetes (41% and 68%, and 12% and 18%, respectively).
  • In 1 study comparing diet only with physical activity only, a similar portion of patients developed diabetes (44% and 41%, respectively).
  • Diet, physical activity, or both had neither a positive nor negative impact on heart attacks or strokes.

Citation:

Hemmingsen B, Gimenez-Perez G, Mauricio D, et al. Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk of developing type 2 diabetes mellitus. Cochrane Database of Syst Rev. 2017, Issue 12. Art. No.: CD003054. doi:10.1002/14651858.CD003054.pub4.

This Week's Must Reads

Cochrane on Clinician-Focused Weight Loss Tactics, Cochrane; 2017 Nov 30; Flodgren, et al

Cochrane on Delaying Diabetes in People with IGT, Cochrane; 2017 Dec 5; Hemmingsen, et al

Consider Using This Risk Tool to Predict T2D Risk, Diabetes Care; ePub 2017 Dec 1; Bergmark, Bhatt, et al

Dysglycemia Cause in Overweight Adults, Teens, Diabetes Care; ePub 2017 Nov 28; Chen, et al

FDA Approves Semaglutide for Type 2 Diabetes, Novo Nordisk news release; 2017 Dec 5

Must Reads in Diabetes

Cochrane on Delaying Diabetes in People with IGT, Cochrane; 2017 Dec 5; Hemmingsen, et al

Consider Using This Risk Tool to Predict T2D Risk, Diabetes Care; ePub 2017 Dec 1; Bergmark, Bhatt, et al

Dysglycemia Cause in Overweight Adults, Teens, Diabetes Care; ePub 2017 Nov 28; Chen, et al

FDA Approves Semaglutide for Type 2 Diabetes, Novo Nordisk news release; 2017 Dec 5

Hospitalization in Those With, Without Diabetes, Diabetes Care; ePub 2017 Nov 17; Burrows, et al